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Suicide attempt in ulcerative colitis patient after 4months of infliximab therapy — A case report

E.J. Eshuisab, K.M.M.Y. Magninc, P.C.F. Stokkersb, W.A. Bemelmana, J. BartelsmanbCorresponding Author Informationemail address

Received 5 March 2010; received in revised form 6 April 2010; accepted 6 April 2010. published online 17 June 2010.
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Abstract 

In the summary of product characteristics of infliximab (IFX), psychiatric side effects are reported to be rare, and in literature only limited data exist. This report presents a case of a patient with ulcerative colitis who developed a depression with psychotic symptoms during IFX therapy and made a suicide attempt 4months after the initiation of therapy. Although the time between start of IFX therapy and onset of symptoms could suggest a correlation, this, of course, does not prove that IFX was the causative factor for his depression and suicide attempt.

a Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands

b Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands

c Department of Psychiatry, Academic Medical Center, Amsterdam, The Netherlands

Corresponding Author InformationCorresponding author. Academic Medical Center, Department of Gastroenterology and Hepatology, PO Box 22660, 1100 DD Amsterdam, The Netherlands. Tel.: +31 20 5669111; fax: +31 20 5669608.

PII: S1873-9946(10)00055-3

doi:10.1016/j.crohns.2010.04.001